These uncontrollable jerking motions, which include normal hiccups and "sleep starts," can be disabling when caused by an underlying health condition.
Myoclonus refers to a quick, involuntary muscle jerk. Hiccups are a form of myoclonus, as are the sudden jerks, or "sleep starts," you may feel just before falling asleep. These forms of myoclonus occur in healthy people and rarely present a problem.
Other forms of myoclonus may occur because of a nervous system (neurological) disorder, such as epilepsy, a metabolic condition, or a reaction to a medication.
Ideally, treating the underlying cause will help control your myoclonus symptoms. If the cause of myoclonus is unknown or can't be specifically treated, then treatment focuses on reducing the effects of myoclonus on your quality of life.
People with myoclonus often describe their signs and symptoms as jerks, shakes or spasms that are:
If your myoclonus symptoms become frequent and persistent, talk to your doctor for further evaluation and proper diagnosis and treatment.
Myoclonus may be caused by a variety of underlying problems. Doctors often separate the types of myoclonus based on their causes, which helps determine treatment. Types of myoclonus include the following categories.
This type of myoclonus occurs in normal, healthy people and rarely needs treatment. Examples include:
Essential myoclonus occurs on its own, usually without other symptoms and without being related to any underlying illness. The cause of essential myoclonus is often unexplained (idiopathic) or, in some cases, hereditary.
This type of myoclonus occurs as part of an epileptic disorder.
Symptomatic myoclonus occurs as a result of an underlying medical condition. Examples include:
Nervous system conditions that result in secondary myoclonus include:
To diagnose myoclonus, your doctor will review your medical history and symptoms and conduct a physical examination.
To determine the cause of myoclonus and rule out other potential causes of your condition, your doctor may recommend several tests, including:
This procedure records the electrical activity of your brain and may help determine where in your brain the myoclonus originates. In this procedure, doctors attach small electrodes to your scalp. You may be asked to breathe deeply and steadily and look at bright lights or listen to sounds, as these actions may uncover abnormal electrical activity.
In this procedure, doctors put EMG surface electrodes on multiple muscles, especially on those muscles that are involved in the jerking.
An instrument records the electrical activity from your muscle at rest and as you contract the muscle, such as by bending your arm. These signals help determine the pattern and origin of the myoclonus.
These tests measure the electrical activity of the brain, brainstem and spinal cord that is triggered by touch, sound, sight and other stimuli.
An MRI scan may be used to check for structural problems or tumors inside your brain or spinal cord, which may cause your myoclonus symptoms. An MRI scan uses a magnetic field and radio waves to produce detailed images of your brain, spinal cord and other areas of your body.
Your doctor may suggest genetic testing to help identify possible causes of myoclonus. He or she may also test your blood or urine to check for:
Treatment of myoclonus is most effective when a reversible underlying cause can be found that can be treated — such as another condition, a medication or a toxin.
Most of the time, however, the underlying cause can't be cured or eliminated, so treatment is aimed at easing myoclonus symptoms, especially when they're disabling. There are no drugs specifically designed to treat myoclonus, but doctors have borrowed from other disease treatment arsenals to relieve myoclonic symptoms. More than one drug may be needed to control your symptoms.
Medications that doctors commonly prescribe for myoclonus include:
Anticonvulsants. Drugs used to control epileptic seizures have proved helpful in reducing myoclonus symptoms. The most common anticonvulsants used for myoclonus are levetiracetam (Keppra, Elepsia XR, Spritam), valproic acid, zonisamide (Zonegran) and primidone (Mysoline). Piracetam is another anticonvulsant that's been found to be effective, but it's not available in the United States.
Valproic acid may cause side effects such as nausea. Levetiracetam may cause side effects such as fatigue and dizziness. Side effects from primidone may include sedation and nausea.
OnabotulinumtoxinA (Botox) injections may be helpful in treating various forms of myoclonus, particularly if only a single area is affected. Botulinum toxins block the release of a chemical messenger that triggers muscle contractions.
If your myoclonus symptoms are caused by a tumor or lesion in your brain or spinal cord, surgery may be an option. People with myoclonus affecting parts of the face or ear also may benefit from surgery.
Deep brain stimulation (DBS) has been tried in some people with myoclonus and other movement disorders. Researchers continue to study DBS for myoclonus.
You'll probably first discuss your concerns with your primary care doctor, who may then refer you to a doctor trained in nervous system conditions (neurologist).
Because appointments can be brief, and because there's often a lot to talk about, it's a good idea to arrive well prepared for your appointment. Here's some information to help you get ready for your appointment, and what to expect from your doctor.
Your time with your doctor is limited, so preparing a list of questions ahead of time will help you make the most of your time together. For myoclonus, some basic questions to ask your doctor include:
In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment at any time that you don't understand something.
Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to spend more time on. Your doctor may ask:
December 24th, 2020
