Learn about diagnosis and treatment for multiple endocrine neoplasia, type 1 (MEN 1) — a rare disorder that causes tumors and overproduction of hormones.
Multiple endocrine neoplasia, type 1 (MEN 1), sometimes called Wermer's syndrome, is a rare disorder that causes tumors in the endocrine glands and parts of the small intestine and stomach. In MEN 1, the endocrine glands — usually the parathyroids, pancreas and pituitary — grow tumors and release excessive amounts of hormones that can lead to disease. However, the tumors are usually noncancerous (benign).
The excess hormones can cause a wide variety of signs and symptoms. These can include tiredness, bone pain, broken bones, kidney stones, and ulcers in the stomach or intestines. MEN 1 can't be cured. But regular testing can detect problems, and doctors can provide treatment as needed.
MEN 1 is an inherited disorder. This means people who have the gene mutation can pass it on to their children. Each child has a 50% chance of inheriting the disorder.
Signs and symptoms of MEN 1 include the following:
Symptoms are caused by the release of too many hormones in the body.
To diagnose multiple endocrine neoplasia, type 1 (MEN 1), your doctor will perform a physical exam and review your medical history and family history. You may have a blood test and imaging tests, including the following:
Genetic testing may determine whether someone has a genetic mutation causing MEN 1. If someone has a mutation, his or her children are at risk of inheriting the mutation and developing MEN 1. Parents and siblings also are at risk of having the mutation even if they have not yet developed symptoms.
If no related genetic changes are found in family members, then no further screening tests are needed. However, genetic testing doesn't uncover all MEN 1 genetic mutations. If genetic testing doesn't confirm MEN 1, but it's likely a person has it, that person and their family members still need close follow-up with appropriate blood and imaging tests.
In MEN 1, tumors can grow on the parathyroids, pancreas and pituitary gland. These tumors can lead to various conditions, all of which can be treated. These conditions and treatments may include:
Metastatic neuroendocrine tumors. Disease that has spread to the lymph nodes or liver may be treated with surgery. Surgery options include liver surgery, radiofrequency ablation, cryoablation or chemoembolization.
Radiofrequency ablation uses high-frequency energy that passes through a needle and causes the surrounding tissue to heat up, killing the nearby cells. Cryoablation involves freezing tumors. And chemoembolization involves injecting strong chemotherapy drugs directly into the liver. When surgery isn't an option, doctors may use other forms of chemotherapy or hormone-based treatments.
November 12th, 2021