Learn about the symptoms, causes, treatment of this chronic condition in which the pancreas produces little or no insulin.
Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin. Insulin is a hormone needed to allow sugar (glucose) to enter cells to produce energy.
Different factors, including genetics and some viruses, may contribute to type 1 diabetes. Although type 1 diabetes usually appears during childhood or adolescence, it can develop in adults.
Despite active research, type 1 diabetes has no cure. Treatment focuses on managing blood sugar levels with insulin, diet and lifestyle to prevent complications.
Type 1 diabetes signs and symptoms can appear relatively suddenly and may include:
Consult your doctor if you notice any of the above signs and symptoms in you or your child.
The exact cause of type 1 diabetes is unknown. Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin-producing (islet, or islets of Langerhans) cells in the pancreas. Other possible causes include:
Once a significant number of islet cells are destroyed, you'll produce little or no insulin. Insulin is a hormone that comes from a gland situated behind and below the stomach (pancreas).
Glucose — a sugar — is a main source of energy for the cells that make up muscles and other tissues.
In type 1 diabetes, there's no insulin to let glucose into the cells, so sugar builds up in your bloodstream. This can cause life-threatening complications.
Some known risk factors for type 1 diabetes include:
Over time, type 1 diabetes complications can affect major organs in your body, including heart, blood vessels, nerves, eyes and kidneys. Maintaining a normal blood sugar level can dramatically reduce the risk of many complications.
Eventually, diabetes complications may be disabling or even life-threatening.
Nerve damage (neuropathy). Excess sugar can injure the walls of the tiny blood vessels (capillaries) that nourish your nerves, especially in the legs. This can cause tingling, numbness, burning or pain that usually begins at the tips of the toes or fingers and gradually spreads upward. Poorly controlled blood sugar could cause you to eventually lose all sense of feeling in the affected limbs.
Damage to the nerves that affect the gastrointestinal tract can cause problems with nausea, vomiting, diarrhea or constipation. For men, erectile dysfunction may be an issue.
There's no known way to prevent type 1 diabetes. But researchers are working on preventing the disease or further destruction of the islet cells in people who are newly diagnosed.
Ask your doctor if you might be eligible for one of these clinical trials, but carefully weigh the risks and benefits of any treatment available in a trial.
Diagnostic tests include:
If the A1C test isn't available, or if you have certain conditions that can make the A1C test inaccurate — such as pregnancy or an uncommon form of hemoglobin (hemoglobin variant) — your doctor may use these tests:
If you're diagnosed with diabetes, your doctor may also run blood tests to check for autoantibodies that are common in type 1 diabetes. These tests help your doctor distinguish between type 1 and type 2 diabetes when the diagnosis is uncertain. The presence of ketones — byproducts from the breakdown of fat — in your urine also suggests type 1 diabetes, rather than type 2.
You'll regularly visit your doctor to discuss diabetes management. During these visits, the doctor will check your A1C levels. Your target A1C goal may vary depending on your age and various other factors, but the American Diabetes Association generally recommends that A1C levels be below 7 percent, which translates to an estimated average glucose of 154 mg/dL (8.5 mmol/L).
Compared with repeated daily blood sugar tests, A1C testing better indicates how well your diabetes treatment plan is working. An elevated A1C level may signal the need for a change in your insulin regimen, meal plan or both.
In addition to the A1C test, the doctor will also take blood and urine samples periodically to check your cholesterol levels, thyroid function, liver function and kidney function. The doctor will also examine you to assess your blood pressure and will check the sites where you test your blood sugar and deliver insulin.
Treatment for type 1 diabetes includes:
The goal is to keep your blood sugar level as close to normal as possible to delay or prevent complications. Generally, the goal is to keep your daytime blood sugar levels before meals between 80 and 130 mg/dL (4.44 to 7.2 mmol/L) and your after-meal numbers no higher than 180 mg/dL (10 mmol/L) two hours after eating.
Anyone who has type 1 diabetes needs lifelong insulin therapy.
Types of insulin are many and include:
Examples of short-acting (regular) insulin include Humulin R and Novolin R. Rapid-acting insulin examples are insulin glulisine (Apidra), insulin lispro (Humalog) and insulin aspart (Novolog). Long-acting insulins include insulin glargine (Lantus, Toujeo Solostar), insulin detemir (Levemir) and insulin degludec (Tresiba). Intermediate-acting insulins include insulin NPH (Novolin N, Humulin N).
Insulin can't be taken orally to lower blood sugar because stomach enzymes will break down the insulin, preventing its action. You'll need to receive it either through injections or an insulin pump.
Injections. You can use a fine needle and syringe or an insulin pen to inject insulin under your skin. Insulin pens look similar to ink pens and are available in disposable or refillable varieties.
If you choose injections, you'll likely need a mixture of insulin types to use throughout the day and night. Multiple daily injections that include a combination of a long-acting insulin combined with a rapid-acting insulin more closely mimic the body's normal use of insulin than do older insulin regimens that only required one or two shots a day. A regimen of three or more insulin injections a day has been shown to improve blood sugar levels.
An insulin pump. You wear this device, which is about the size of a cellphone, on the outside of your body. A tube connects a reservoir of insulin to a catheter that's inserted under the skin of your abdomen. This type of pump can be worn in a variety of ways, such as on your waistband, in your pocket or with specially designed pump belts.
There's also a wireless pump option. You wear a pod that houses the insulin reservoir on your body that has a tiny catheter that's inserted under your skin. The insulin pod can be worn on your abdomen, lower back, or on a leg or an arm. The programming is done with a wireless device that communicates with the pod.
Pumps are programmed to dispense specific amounts of rapid-acting insulin automatically. This steady dose of insulin is known as your basal rate, and it replaces whatever long-acting insulin you were using.
When you eat, you program the pump with the amount of carbohydrates you're eating and your current blood sugar, and it will give you what's called a bolus dose of insulin to cover your meal and to correct your blood sugar if it's elevated. Some research has found that in some people an insulin pump can be more effective at controlling blood sugar levels than injections. But many people achieve good blood sugar levels with injections, too. An insulin pump combined with a continuous glucose monitoring (CGM) device may provide even tighter blood sugar control.
In September 2016, the Food and Drug Administration approved the first artificial pancreas for people with type 1 diabetes who are age 14 and older. A second artificial pancreas was approved in December 2019.
It's also called closed-loop insulin delivery. The implanted device links a continuous glucose monitor, which checks blood sugar levels every five minutes, to an insulin pump. The device automatically delivers the correct amount of insulin when the monitor indicates it's needed.
There are more artificial pancreas (closed loop) systems currently in clinical trials.
Additional medications also may be prescribed for people with type 1 diabetes, such as:
Depending on what type of insulin therapy you select or require, you may need to check and record your blood sugar level at least four times a day.
The American Diabetes Association recommends testing blood sugar levels before meals and snacks, before bed, before exercising or driving, and if you suspect you have low blood sugar. Careful monitoring is the only way to make sure that your blood sugar level remains within your target range — and more frequent monitoring can lower A1C levels.
Even if you take insulin and eat on a rigid schedule, blood sugar levels can change unpredictably. You'll learn how your blood sugar level changes in response to food, activity, illness, medications, stress, hormonal changes and alcohol.
Continuous glucose monitoring (CGM) is the newest way to monitor blood sugar levels, and may be especially helpful for preventing hypoglycemia. The devices have been shown to lower A1C.
Continuous glucose monitors attach to the body using a fine needle just under the skin that checks blood glucose level every few minutes. CGM isn't yet considered as accurate as standard blood sugar monitoring, so at this time it's still important to check your blood sugar levels manually.
There's no such thing as a diabetes diet. However, it's important to center your diet on nutritious, low-fat, high-fiber foods such as:
Your dietitian will recommend that you eat fewer animal products and refined carbohydrates, such as white bread and sweets. This healthy-eating plan is recommended even for people without diabetes.
You'll need to learn how to count the amount of carbohydrates in the foods you eat so that you can give yourself enough insulin to properly metabolize those carbohydrates. A registered dietitian can help you create a meal plan that fits your needs.
Everyone needs regular aerobic exercise, and people who have type 1 diabetes are no exception. First, get your doctor's OK to exercise. Then choose activities you enjoy, such as walking or swimming, and make them part of your daily routine. Aim for at least 150 minutes of aerobic exercise a week, with no more than two days without any exercise. The goal for children is at least an hour of activity a day.
Remember that physical activity lowers blood sugar. If you begin a new activity, check your blood sugar level more often than usual until you know how that activity affects your blood sugar levels. You might need to adjust your meal plan or insulin doses to compensate for the increased activity.
Certain life circumstances call for different considerations.
Being pregnant. Because the risk of pregnancy complications is higher for women with type 1 diabetes, experts recommend that women have a preconception evaluation and that A1C readings ideally should be less than 6.5% before they attempt to get pregnant.
The risk of birth defects is increased for women with type 1 diabetes, particularly when diabetes is poorly controlled during the first six to eight weeks of pregnancy. Careful management of your diabetes during pregnancy can decrease your risk of complications.
Despite your best efforts, sometimes problems will arise. Certain short-term complications of type 1 diabetes, such as hypoglycemia, require immediate care.
Low blood sugar (hypoglycemia). This occurs when your blood sugar level drops below your target range. Ask your doctor what's considered a low blood sugar level for you. Blood sugar levels can drop for many reasons, including skipping a meal, eating fewer carbohydrates than called for in your meal plan, getting more physical activity than normal or injecting too much insulin.
Learn the symptoms of hypoglycemia, and test your blood sugar if you think your levels are dropping. When in doubt, always test your blood sugar. Early signs and symptoms of low blood sugar include:
Later signs and symptoms of low blood sugar, which can sometimes be mistaken for alcohol intoxication in teens and adults, include:
Nighttime hypoglycemia may cause you to wake with sweat-soaked pajamas or a headache. Due to a natural rebound effect, nighttime hypoglycemia sometimes might cause an unusually high blood sugar reading first thing in the morning, also known as Somogyi effect.
If you have a low blood sugar reading:
If a blood glucose meter isn't readily available, treat for low blood sugar anyway if you have symptoms of hypoglycemia, and then test as soon as possible.
Left untreated, low blood sugar will cause you to lose consciousness. If this occurs, you may need an emergency injection of glucagon — a hormone that stimulates the release of sugar into the blood. Be sure you always have an unexpired glucagon emergency kit available at home, at work and when you're out. Make sure that co-workers, family and friends know how to use the kit in case you are unable to give yourself the injection.
Hypoglycemia unawareness. Some people may lose the ability to sense that their blood sugar levels are getting low, called hypoglycemia unawareness. The body no longer reacts to a low blood sugar level with symptoms such as lightheadedness or headaches. The more you experience low blood sugar, the more likely you are to develop hypoglycemia unawareness. If you can avoid having a hypoglycemic episode for several weeks, you may start to become more aware of impending lows. Sometimes increasing the blood sugar target (for example, from 80 to 120 mg/DL to 100 to 140 mg/DL) at least temporarily can also help improve hypoglycemia awareness.
High blood sugar (hyperglycemia). Your blood sugar can rise for many reasons, including eating too much, eating the wrong types of foods, not taking enough insulin or fighting an illness.
If you suspect hyperglycemia, check your blood sugar. If your blood sugar is higher than your target range, you'll likely need to administer a "correction" — an additional dose of insulin that should bring your blood sugar back to normal. High blood sugar levels don't come down as quickly as they go up. Ask your doctor how long to wait until you recheck. If you use an insulin pump, random high blood sugar readings may mean you need to change the pump site.
If you have a blood sugar reading above 240 mg/dL (13.3 mmol/L), test for ketones using a urine test stick. Don't exercise if your blood sugar level is above 240 mg/dL or if ketones are present. If only a trace or small amounts of ketones are present, drink extra fluids to flush out the ketones.
If your blood sugar is persistently above 300 mg/dL (16.7 mmol/L), or if your urine ketones remain high despite taking appropriate correction doses of insulin, call your doctor or seek emergency care.
Increased ketones in your urine (diabetic ketoacidosis). If your cells are starved for energy, your body may begin to break down fat — producing toxic acids known as ketones. Diabetic ketoacidosis is a life-threatening emergency.
Signs and symptoms of this serious condition include:
If you suspect ketoacidosis, check your urine for excess ketones with an over-the-counter ketones test kit. If you have large amounts of ketones in your urine, call your doctor right away or seek emergency care. Also, call your doctor if you have vomited more than once and you have ketones in your urine.
Careful management of type 1 diabetes can reduce your risk of serious — even life-threatening — complications. Consider these tips:
Keep your vaccinations up to date. High blood sugar can weaken your immune system. Get a flu shot every year. Your doctor will likely recommend the pneumonia vaccine, as well.
The Centers for Disease Control and Prevention (CDC) recommends hepatitis B vaccination if you haven't previously been vaccinated against hepatitis B and you're an adult ages 19 to 59 with type 1 or type 2 diabetes. The CDC advises vaccination as soon as possible after diagnosis with type 1 or type 2 diabetes. If you are age 60 or older and have diabetes and haven't previously received the vaccine, talk to your doctor about whether it's right for you.
Diabetes can affect your emotions both directly and indirectly. Poorly controlled blood sugar can directly affect your emotions by causing behavior changes, such as irritability. There may be times you feel resentful about your diabetes.
People with diabetes have an increased risk of depression and diabetes-related distress, which may be why many diabetes specialists regularly include a social worker or psychologist as part of their diabetes care team.
You may find that talking to other people with type 1 diabetes is helpful. Support groups are available both online and in person. Group members often know about the latest treatments and tend to share their own experiences or helpful information, such as where to find carbohydrate counts for your favorite takeout restaurant.
If you're interested in a support group, your doctor may be able to recommend one in your area. Or you can visit the websites of the American Diabetes Association (ADA) or the Juvenile Diabetes Research Foundation (JDRF) for support group information and to check out local activities for people with type 1 diabetes. You can also reach the ADA at 800-DIABETES (800-342-2383) or JDRF at 800-533-CURE (800-533-2873).
If you suspect that you or your child might have type 1 diabetes, get evaluated immediately. A simple blood test can let your doctor know if you need further evaluation and treatment.
After diagnosis, you'll need close medical follow-up until your blood sugar level stabilizes. A doctor who specializes in hormonal disorders (endocrinologist) generally coordinates diabetes care. Your health care team will likely include:
Once you've learned the basics of managing type 1 diabetes, your endocrinologist likely will recommend checkups every few months. A thorough yearly exam and regular foot and eye exams also are important — especially if you're having a hard time managing your diabetes, if you have high blood pressure or kidney disease, or if you're pregnant.
These tips can help you prepare for your appointments and know what to expect from your doctor.
Preparing a list of questions can help you make the most of your time with your doctor and the rest of your health care team. For type 1 diabetes, topics you want to clarify with your doctor, dietitian or diabetes educator include:
Your doctor is likely to ask you a number of questions, including:
If you're having trouble managing your blood sugar or you have questions, don't hesitate to contact your health care team in between appointments.
September 20th, 2021