Hypereosinophilic syndrome is a disorder of certain types of white blood cells that can cause life-threatening damage to your organs.
Hypereosinophilic (hy-per-ee-o-SIN-o-phil-ik) syndrome (HES) is a group of blood disorders that occur when you have high numbers of eosinophils — white blood cells that play an important role in your immune system. Over time, the excess eosinophils enter various tissues, eventually damaging your organs.
The most common targets are the skin, lungs, digestive tract, heart, blood and nervous system. Untreated, HES can become life-threatening.
Early symptoms of HES may include fatigue, cough, breathlessness, muscle pain, rash and fever.
Some varieties of hypereosinophilic syndrome tend to run in families. Other types have been associated with certain types of cancers, infections or other health problems.
HES can affect anyone. But it occurs more often in men, usually between the ages of 20 and 50.
Many types of disorders can raise your eosinophil level, including certain infections, allergies and reactions to medications. When trying to determine whether you have hypereosinophilic syndrome (HES), your doctor is likely to ask about your travel history and any medications you're taking, to help rule out these other causes.
Your doctor may also need information from some of the following lab tests:
Imaging tests may include:
Treatment for hypereosinophilic syndrome is aimed at reducing your eosinophil count to prevent tissue damage, especially to your heart. Specific treatment depends on your symptoms, the severity of your condition and the cause of your HES.
If you have no symptoms and your eosinophil count is low enough, you might require no treatment other than close monitoring for any changes related to HES.
Systemic corticosteroids, such as prednisone, are the first line treatment. Other treatment options include:
Because HES can increase your risk of blood clots, you might also be prescribed blood-thinning medications such as warfarin (Coumadin).
If nothing else has worked, your doctor might suggest a stem cell or bone marrow transplant.
You'll likely first bring your symptoms to the attention of your family doctor. Depending on your symptoms, you may be referred to specialists in blood diseases (hematology), heart conditions (cardiology) or allergies.
Consider taking a relative or friend along to the appointment to help remember all the information provided.
Here's some information to help you get ready for the appointment, and what to expect from the doctor.
Before your appointment, make a list of:
For hypereosinophilic syndrome, some basic questions to ask the doctor include:
The doctor is likely to ask you several questions. Be ready to answer them to allow time later to cover other points you want to address. Examples include:
December 24th, 2020